(Utrogestan) Progesterone 100mg

(Oestrogel) Estradiol 750 μg/actuation

Please read the full information about warnings for Oestrogel and Utrogestan as detailed in your Patient Information Leaflets.

You should go for regular breast screening and smear tests.

You should also check your breasts regularly and see your doctor if you notice changes such as dimpling of the skin, nipple changes or you can see or feel any lumps.

There is an increased risk of risk of developing blood clots with HRT tablets. You should stop taking Oestrogel and Utrogestan and see a doctor if you notice signs of a blood clot.

Oestrogel should not be applied to the breasts and face or any areas of irritated or broken skin.

If you still have an intact uterus, you should be using this combination of both products rather than Oestrogel alone. By using Utrogestan alongside Oestrogel, this reduces your risk of developing certain cancers.

HRT

Oestrogel dosing schedule: 2 pump actuations per day.

Utrogestan dosing schedule: Either one capsule at bedtime on Days 1 to 25 of a cycle. Or two capsules at bedtime on Days 15 to 26.

How to use Oestrogel:

• Application sites should be rotated daily.
• Before use: wash and dry your hands and application areas thoroughly.
• After applying: Leave the gel to dry for 5 minutes before covering

You have, or have ever had breast cancer, or any form of cancer sensitive to oestrogens. those with active cancer or those with 3 years of cancer remission.

You have unexplained vaginal bleeding. those with active cancer or those with 3 years of cancer remission.

You have excessive thickening of the womb lining endometrial hyperplasia that is not being treated. those with active cancer or those with 3 years of cancer remission.

You have, or have ever had a blood clot in the vein (such as DVT in the legs) those with active cancer or those with 3 years of cancer remission.

You have a blood clotting disorder. those with active cancer or those with 3 years of cancer remission.

You have, or have ever had a heart attack, stroke or angina. those with active cancer or those with 3 years of cancer remission.

You have, or have ever had liver disease and your liver function levels are still not normal. those with active cancer or those with 3 years of cancer remission.

You have a rare blood condition called porphyria. those with active cancer or those with 3 years of cancer remission.

Oestrogel: Painful, heavy periods, Irregular bleeding, White or yellow vaginal discharge.

Utrogestan: Stomach pain, Nausea, Vomiting, Constipation, Diarrhoea, Dizziness, Headaches, Drowsiness, Intense itching, Breast pain, Irregular bleeding

Oestrogel: Carbomer, trolamine, ethanol and purified water.

Utrogestan: Sunflower oil, soya lecithin, gelatin, glycerol, titanium dioxide, purified water.

No special storage requirements .